EDS is a group of connective tissue disorders caused by defects in collagen that lead to a variety of symptoms including joint hypermobility, skin fragility, chronic pain, and autonomic nervous system dysfunction.
Important: Not all patients with EDS are hypermobile.
Hypermobility syndromes and EDS are related but distinct, and while many patients with EDS show hypermobility, it is not universal.
This distinction is important when considering the overlap with Pediatric Long COVID. Doctors often mistakenly believe that all EDS patients suffer from hypermobility based on old classifications, and mistakenly rule it out.
It is my clinical experience that EDS is shockingly underdiagnosed.
Here are some of the most common signs, symptoms and secondary conditions associated with hEDS:
It is very important to note that hypermobility is no longer the sole or absolute criterion for diagnosing EDS. The current 2017 international classification of EDS places emphasis on a combination of factors for diagnosing hEDS, which includes (19):
Research suggests COVID-19 may trigger or worsen autonomic nervous system dysregulation, a common feature in EDS and hypermobility disorders.
The connection between EDS, hypermobility, and Pediatric Long COVID likely stems from immune activation, persistent inflammation, and nervous system instability caused by the viral infection, which may exacerbate underlying connective tissue vulnerabilities and autonomic dysfunction. Even patients with non-hypermobile forms of EDS may be at increased risk for prolonged or severe Long COVID symptoms due to pre-existing tissue fragility and dysautonomia. This overlap complicates diagnosis and treatment but highlights the need for multidisciplinary, individualized care focusing on autonomic symptom management, physical therapy, and supportive treatments.
Ongoing research aims to clarify how different EDS subtypes influence Long COVID outcomes in children and to develop targeted management strategies. Clinicians should recognize that the absence of hypermobility does not exclude EDS or connective tissue-related risks in Long COVID, emphasizing thorough assessment and personalized treatment plans.
If you’ve been told “it’s just anxiety,” “they’ll grow out of it,” or “it’s only flexibility,” take heart. Recognizing EDS features in the setting of Long COVID doesn’t limit your child’s future; it focuses care on what their body needs to feel safe and stable again.
With compassionate, individualized support—and a plan that centers nervous system balance, joint stability, and GI/autonomic regulation—kids can steadily reclaim energy, movement, and joy.
Disclaimer: The information written on this website is designed to provide helpful information on various conditions and the subjects discussed. This website is not meant to be used to diagnose or treat any medical condition or to replace the advice of your physician(s). The author of this website does not claim to treat, diagnose or cure Long COVID, CRPS, EDS/POTS, AMPS, or any other specific condition or infection. The Spero Clinic treats the central nervous system only, often resulting in the body being able to heal itself.
You should regularly consult a physician in matters relating to your health, particularly with respect to any symptoms that may require diagnosis or medical attention. For diagnosis or treatment of any medical problem, consult your own physician(s).
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