When a child is recovering from Long COVID, new problems can appear that don’t feel connected at first. One of the most challenging is Complex Regional Pain Syndrome (CRPS)—a chronic pain condition where the body’s pain alarm gets “stuck on.” Understanding what it is, why it can show up after illness or injury, and what to watch for can make a real difference for families.
Several case studies have documented the onset of CRPS after COVID-19 infection. For instance, a case study described a patient who developed CRPS type 1 following a COVID-19 infection, suggesting a potential link between the virus and the development of CRPS (4). Another report detailed a case of CRPS in a patient after severe COVID-19, highlighting the potential neurological complications associated with the virus (5). Although there are no studies yet about the link between Long COVID and CRPS, we have treated several pediatric patients who developed CRPS shortly after a COVID-19 infection. It is therefore my belief that COVID is a definite risk factor for CRPS.
The exact mechanism by which COVID-19 may lead to CRPS is not fully understood, but it is hypothesized that the virus’s impact on the nervous system and immune response could play a role. These findings underscore the importance of monitoring for chronic pain conditions like CRPS in patients recovering from COVID-19.
CRPS often follows surgery or minor trauma. To protect your child:
Equipment caution: Tight-fitting braces, boots, or compression wear may be necessary briefly, but overuse without movement can raise risk in susceptible children. Ensure proper fit and encourage gentle motion of toes/fingers and nearby joints as allowed.
Therefore, it is crucial to obtain a correct diagnosis as soon as possible. Sadly, because CRPS is so rare and misunderstood, many doctors will misdiagnose it or miss it altogether. It can sometimes present with tell-tale signs, such as loss of hair, shiny skin, discoloration, swelling and even blisters and scabs. However, sometimes it can present without physical signs. Children especially may face an uphill battle being believed by their healthcare team. Please familiarize yourself with the early signs and symptoms of this condition, which usually (but not always) develop after surgeries or injuries.
In order to protect your child, be aware of the following:
**If ANY of these signs persist, insist that CRPS is ruled out by a knowledgeable clinician.
Reach out to a clinician familiar with pediatric CRPS if your child develops two or more of the following—especially after COVID-19, injury, or surgery:
Prompt evaluation can open doors to nervous-system–supportive care, desensitization, targeted physical therapy, and home strategies that keep kids engaged in life while they heal.
Disclaimer: The information written on this website is designed to provide helpful information on various conditions and the subjects discussed. This website is not meant to be used to diagnose or treat any medical condition or to replace the advice of your physician(s). The author of this website does not claim to treat, diagnose or cure Long COVID, CRPS, EDS/POTS, AMPS, or any other specific condition or infection. The Spero Clinic treats the central nervous system only, often resulting in the body being able to heal itself.
You should regularly consult a physician in matters relating to your health, particularly with respect to any symptoms that may require diagnosis or medical attention. For diagnosis or treatment of any medical problem, consult your own physician(s).
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