Ehlers-Danlos Syndrome (EDS) is an inherited heterogeneous group of connective tissue disorders, however, genetics alone do not determine whether someone will experience the symptoms of EDS. Epigenetics—the way environmental factors influence gene expression—plays a crucial role in triggering or exacerbating EDS symptoms. Chronic stress and nervous system dysregulation are key contributors to epigenetic modifications that impact EDS-related genes.
Epigenetics is the ability to alter the expression of our genes by “epi” (influencing factors outside of our bodies). In other words, the way we live can influence the expression of our genes. These changes are influenced by external factors such as stress, diet, trauma, and environmental toxins. Essentially, epigenetics acts as a switch that can turn genes “on” or “off,” affecting how our bodies function.
While someone may have a genetic predisposition for EDS, the severity and manifestation of the condition can be influenced by environmental factors. Chronic stress and nervous system dysregulation are key contributors to epigenetic modifications that impact EDS-related genes.
When the nervous system is overwhelmed by chronic stress, infections, or toxins, it can trigger these genetic expressions, leading to symptomatic EDS.
Several environmental factors can contribute to nervous system dysregulation and, in turn, trigger EDS symptoms:
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