The Ehlers-Danlos syndromes (EDS) are currently classified in a recognized system of thirteen subtypes. The age at which Ehlers-Danlos syndrome (EDS) symptoms appear varies depending on the subtype of EDS and the symptoms they suffer from, as EDS will present differently for each patient.
Depending on the type of EDS and individual, symptoms can appear as early as infancy and as late as late adulthood. For example,
Classical EDS (cEDS): Symptoms often appear in childhood or adolescence. However, the diagnosis is often delayed until adulthood due to milder symptoms.
Hypermobile EDS (hEDS): Symptoms often appear in childhood or adolescence. However, the diagnosis is often delayed until late adulthood due to subtle signs and challenges with diagnostic tools for assessing generalized joint hypermobility (GJH).
Vascular EDS (vEDS): This is a more severe subtype of EDS. Severe complications, such as vascular dissection or rupture, GI perforation, or organ rupture are the presenting signs in most adults with vEDS. However, symptoms may appear earlier on in life, such as childhood, due to fragile blood vessels and skin. For example, arterial rupture may present at a young age.
Dermatosparaxis EDS (dEDS) and Musculocontractural EDS (mcEDS): Symptoms and characteristics can be evident at birth or early infancy or as late as adolescence or adulthood.
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